LONDON (Reuters) - Scientists have found a genetic mechanism in mice that hampers their body clock's ability to adjust to changes in patterns of light and dark, and say their results could someday lead to the development of drugs to combat jet lag.
Researchers from Britain's Oxford University and from the Swiss drug firm Roche used mice to analyze patterns of genes in an area of the brain called the suprachiasmatic nuclei (SCN) - which in mammals pulls every cell in the body into the same biological rhythm.
They found that one molecule, called SIK1, is key to how the mice responded to changes in light cycles.
When the scientists blocked the activity of SIK1, the mice recovered faster from disturbances in their daily light and dark cycle that had been designed to induce a form of mouse jet lag.
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